研究

氢的简史

有没有想过“氢”这个名字的来源?“氢”这名字源于希腊文字“Hydro”(水)和“genes”(形成),因为氢是形成水的两个元素之一。法语单词“Hydrogene”用来形容“氢气”,这个名字是由法国科学家Antoine Lavoisier创造,他也被称为现代化学之父。

虽然连接氢气和医药的最早出版物之一发表于18世纪,但直到2007年,由I.Ohsawa等人领导的日本科学家团队发现,氢气吸入时可作为治疗性抗氧化剂,并保护身体细胞免受自由基的伤害。该研究和发现首次发表于Nature Medicine(2007)。这具有里程碑意义的出版物引发了全球对其潜在健康裨益的兴趣。从那时起,已有超过1,000项关于氢及其对170多种人类疾病以及人体各器官益处的研究。

2013年,Tyler LeBaron开创并建立氢分子研究所(MHI)。MHI是氢分子科学的权威代表,其主要宗旨是发展、促进、教育和宣传氢研究,并保持氢研究和氢产品的完整性。

氢分子(H2)是由两个氢原子组成的天然分子。基于它两个原子的组成,它是宇宙中最小和最丰富的分子。作为最小的分子,氢可以穿透人体细胞和组织,包括血脑屏障。

氢是一种无色、无味、无毒的气体,对人类疾病具有多种治疗益处,其中包括作为强大的抗氧化剂(和选择性抗氧化),抗炎症,抗细胞凋亡(抗细胞死亡)和抗过敏。有各种使用氢的方法,例如:通过摄取、吸入、注射、喷洒在皮肤上,或透过沐浴吸收。

什么是分子氢
它如何在我的体内起作用?

自由基的危害

自由基是不稳定分子,拥有一个或多个不成对电子,使其具有高反应性。因此,它们从我们体内的其他稳定分子中窃取一个或多个电子,导致身体细胞受到损害和破坏。当自由基生成与身体抵抗或中和这些有害作用的能力之间失去平衡时,一种被称为氧化应激的情况就会发生。长期氧化应激与蛋白质、脂类和核酸(DNA)的损害有关。

研究表明,如果让这些自由基失控并引起氧化应激,它们会刺激伤害感受器并引起疼痛。 肌筋膜组织中氧化应激的存在很容易在肌肉和关节中产生炎症反应。 在慢性肌肉和关节疾病中,组织中存在慢性炎症和氧化应激是不可分割的。 因此,为了正确处理慢性肌肉和关节问题,需要学习如何管理慢性炎症和氧化应激的代谢因子。

格雷格·佛斯(Greg Fors)《Why We Hurt: A Complete Physical & Spiritual Guide to Healing Your Chronic Pain》。

分子氢是最有潜能的“新型”抗氧化剂

分子氢已被科学证明具有抗氧化特性,有助于从体内清除导致过早衰老的自由基。 Shigeo Ohta博士及其研究人员提出,分子氢具有作为“新型”抗氧化剂的潜力,而不会产生不利影响。

氢作为潜在的抗氧化剂具有许多优点:H2迅速扩散到组织和细胞中,并且其温和程度既不会干扰代谢性氧化还原反应,也不会干扰在细胞信号传导中起作用的活性氧(ROS),因此,几乎没有不良反应消耗氢气的效果。 此外,H2不仅显示出对氧化应激的作用,而且还显示出各种抗炎作用。 H2穿过血脑屏障,尽管大多数抗氧化剂不能。

Source Of Anitioxidant
如何在食品中发现类似于分子氢的植物性抗氧化剂?
  • 它们对都是自然的。
  • 它们既不是人造的也不是合成的。
  • 它们俩都在促进健康。

分子氢与食品中的抗氧化剂有何不同?

  • 分子氢只清除有害的自由基。
  • 分子氢在中和自由基后不会留下废物。
  • 分子氢还可以增强人体自身的抗氧化系统。
  • 分子氢还充当信号分子,因此具有许多其他好处。
  • 分子氢是最小的分子,可以很容易地进入细胞。 (注意:H2仅重2g / mol,而维生素C为176.2 g / mol)
  • 分子氢在高摄入量下没有已知的毒性作用。

哪一个可以消除更多的自由基:维生素C或分子氢?

基于化学计量,一个分子的维生素C在理论上可以中和两个自由基,这与分子氢相同。 但是,一些用过的维生素C分子可以使身体恢复活力并再次使用,而分子氢公司则不然。 另一方面,分子氢可以上调体内强大的抗氧化酶,从而提供进一步的保护,这是维生素C不能实现的功能。 有趣的是,高水平的维生素C摄入实际上可以防止这种上调的发生。

Interview with Professor Shigeo Ohta, Nippon Medical School, Japan; Pioneer Researcher in the Field of Hydrogen as a Therapeutic Antioxidant by selectively reducing Cytotoxic Oxygen Radicals​

A discussion about therapeutic hydrogen gas between Tyler W. LeBaron, Executive Director of the Molecular Hydrogen Institute (MHI), and pioneer hydrogen researcher, Dr. Shigeo Ohta

COVID-19 Pathophysiology & the Rationale for why Molecular Hydrogen is being clinically investigated​

Update on information relating to the benefits of hydrogen for the coronavirus.

Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID-19 patient ~ Ram B. Singh, Ghazi Halabi, Ghizal Fatima, Richa H. Rai, Alexander T. Tarnava, Tyler W. LeBaron Clinical Case Reports (2021)

An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions ~ Tyler W. LeBaron, Jason Kharman, Michael L. McCullough Journal of Integrative Neuroscience (2021)

Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism ~ Naomi Kamimura, Harumi Ichimiya, Katsuya Iuchi and Shigeo Ohta NPJ Aging and Mechanisms of Disease (2016)

Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress ~ Cestmir Cejka, Jan Kossl Barbora Hermankova Vladimir Holan and Jitka Cejkova Hindawi Oxidative Medicine and Cellular Longevity (2017)

Molecular Hydrogen Attenuates Neuropathic Pain in Mice ~ Masanori Kawaguchi, Yasushi Satoh, Yukiko Otsubo, Tomiei Kazama PLOS One (2014)

Hydrogen therapy may help severely ill COVID-19 patients ~ Dr. Ananya Mandal, MD News-Medical.net (2020)

Therapeutic potential of molecular hydrogen in ovarian cancer ~ Lei Shang, Fei Xie, Jiala Li, Yating Zhang, Mengyu Liu, Pengxiang Zhao, Xuemei Ma Tyler W. Lebaron Translational Cancer Research (2018)

The Effects of 24-Week, High-Concentration Hydrogen rich water on Body Composition, Blood Lipid and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial ~ Tyler W LeBaron, Ram B Singh, Ghizal Fatima, Kumar Kartikey, Jagdish P Sharma, Sergej M Ostojic, Anna Gvozdjakova, Branislav Kura, Mami Noda, Viliam Mojto, Mohammad Arif Niaz, Jan SlezakDove Press journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (2020)

Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems ~ Miroslav Barancik, Branislav Kura, Tyler W. LeBaron, Roberto Bolli, Jozef Buday and Jan Slezak Antioxidants (2020)

Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/ EZH2 axis ~ Baocheng Zhu, Hengguan Cui and Weiqiang Xu Cancer Cell Int (2021)

Oral hydrogen water prevents chronic allograft nephropathy in rats ~ Jon S. Cardinal, Jianghua Zhan, Yinna Wang, Ryujiro Sugimoto, Allan Tsung, Kenneth R. McCurry, Timothy R. Billiar and Atsunori Nakao International Society of Nephrology (2010)

Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β Induced Sirt ~ Zhaoyu Xing, Wanma Pan, Jing Zhang, Xianlin Xu, Xuemei Zhang, Xiaozhou He, and Min Fan Biol. Pharm. Bull. (2017)

Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats ~ Wan-Jun Zhu, Masaaki Nakayama, Takefumi Mori, Keisuke Nakayama, Junichiro Katoh, Yaeko Murata, Toshinobu Sato, Shigeru Kabayama, and Sadayoshi Ito Nephrol Dial Transplant (2011)

Hydrogen‐rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double‐blind, controlled trial ~ Minju Sim, Chong‐Su Kim, Woo‐Jeong Shon, Young‐Kwan Lee, Eun Young Choi & Dong‐Mi Shin Scientific Reports | nature research (2020)

Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis ~ Yijun Zheng and Duming Zhu Oxidative Medicine and Cellular Longevity (2016)

Disease models and human diseases for which beneficial effects of hydrogen have been documented ~ Edited June 10, 2019 (Ver. 2.7)

Organ preservation solution containing dissolved hydrogen gas from a hydrogen- absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs ~ Eiji Kobayashi, Motoaki Sano PLOS (2019).

Selective protective effect of hydrogen water on free radical injury of athletes after high-intensity exercise. Yue-Peng Sun, Liang Sun Biomedical Research (2017)

Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress statusJonatas E Nogueira, Patricia Passaglia, Clarissa M. D. Mota & Bruna Maitan Santos Free Radical Biology and Medicine (2018)

Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives S. M. Ostojic International Journal of Sports Medicine (2014)

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes Tyler LeBaron, Ismail Laher, Branislav Kura, Jan Slezak Canadian Journal of Physiology and Pharmacology (2019)

Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life Kei Mizuno, Akihiro T. Sasaki, Kyoko Ebisu, Kanako Tajima, Osami Kajimoto, Junzo Nojima, Hirohiko Kuratsune, Hiroshi Hori, Yasuyoshi Watanabe Medical Gas Research (2018)

Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes Medicine ~ Kosuke Aoki, Atsunori Nakao, Takako Adachi, Yasushi Matsui and Shumpei Miyakawa. Medical Gas Research (2012)

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine ~ Garth L. Nicolson and Shigeo Ohta. International Journal of Clinical Medicine (2016).

Hydrogen acts as a Therapeutic Antioxidant by selectively reducing cytotoxic oxygen radicals ~ S.Ohta et al, Nippon Medical School, Japan. Nature Medicine  (2007).

Recent advances in Hydrogen research as a therapeutic medical gas ~ T. Kawamura et al. Free Radical Research (2010).

Molecular Hydrogen: New antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases ~ T. Ishibashi, Haradoi Hospital, Japan. Current Pharmaceutical Design (2013).

Hydrogen: another gas with Therapeutic Potential ~ James F. George and Anupam Agarwal. Kidney International (2010).

Molecular Hydrogen as an Emerging Candidate for Preventing Alzheimer's Disease ~ Shigeo Ohta and Takashi Asada. Int. J Alzheimers & Neuro Disorder 2018

Molecular Hydrogen improves Obesity and Diabetes by inducing hepatic FGF21 and stimulating energy metabolism in mice ~ Kamimura N1, Nishimaki K, Ohsawa I, Ohta S. NCBI US National Library of Medicine National Institutes of Health

Recent Advances in Hydrogen Research as a Therapeutic Medical Gas ~ Chien Sheng Huang, Tomohiro Kawamura, Yoshiya Toyoda, Atsunori Nakao. Free Radical Research (2010).

Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications ~ Shigeo Ohta. Current Pharmaceutical Design (2011).

Therapeutic efficacy of infused Molecular Hydrogen in saline on Rheumatoid Arthritis ~ Toru Ishibashi. International Immunopharmacology Journal (2014)

Beneficial Effects of Hydrogen-Rich Saline on Early Burn-Wound Progression in Rats ~ Song Xue Guo, Yun Yun Jin, Quan Fang, Chuan Gang You, Xin Gang Wang, Xin Lei Hu, Chun-Mao Han. PLOS ONE (2015).

Can Hydrogen retard the progression of Osteoarthritis ~ Ding Li and WanChun Wang. African Journal of Pharmacy and Pharmacology Vol. 6(5), 2012.

Molecular Hydrogen: An overview of its Neurobiological effects and Therapeutic potential for Bipolar disorder and Schizophrenia ~ Ahmad Ghanizadeh and Micheal Berk. Medical Gas Research (2013).

Hydrogen Gas in Cancer Treatment ~ Sai Li, Rongrong Liao, Xiaoyan Sheng, Xiaojun Luo, Xin Zhang, Xiaomin Wen, Jin Zhou and Kang Peng frontiers in Oncology

Hydrogen – Therapeutic Potential in Wellness and Medicine ~ M. Lemaire & F. Barbier Journal of Aging Research & Clinical Practice

Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia, the 7th Trial Edition ~ National Health Commission of the People's Republic of China, 2020-03-05 [WHO Translation]

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study ~ Toshio Mikami, Kohei Tano, Hosung Lee, Hyowon Lee, Jonghyuk Park, Fumiaki Ohta, Tyler W. LeBaron, Shigeo Ohta. Canadian Journal of Physiology and Pharmacology

Hydrogen therapy for Covid-19 acute respiratory distress syndrome (ARDS) ~ Medium

A novel functional beverage for COVID-19 and other conditions: Hypothesis and preliminary data, increased blood flow, and wound healing ~ LeBaron TW, McCullough ML and Ruppman Sr KH. Journal of Translational Science